CFM's ground-breaking drug VANADIS® offers a new fundamental mechanism for damaged tissue protection.

The compound

CFM has developed VANADIS® a platform of organovanadium compounds and delivery technologies. This compound, BMOV (bis(maltolato)oxidovanadium (IV)) is an organic molecule:

compound

Effect of VANADIS® on cells

VANADIS® has an effective protective mechanism that helps to keep traumatized (but still) healthy cells alive and that stimulates repair of damaged tissue. Preclinical research results have demonstrated this positive effect for multiple trauma indications.

Application area’s of VANADIS®

CFM Pharma has a number of important applications of VANADIS® under development:

  • Treatment of patients with Myocardial Infarction. Preclinical studies have shown that the size of the infarction can be limited significantly.
  • Treatment of Deep Skin Burns, Diabetic and General Wounds. Preclinical studies show that the affected tissue regenerates better and that up to 90% reduction in tissue damage can be achieved.
  • Treatment of other trauma indications like Acute Kidney Injury. Preclinical studies have shown that VANADIS® can limit reperfusion injury in kidneys during acute renal failure.

Given the broad applicability of VANADIS® in trauma conditions, more indications are planned to be developed in the future, including treatment of Brain Infarcts (Stroke).

VANADIS® can be used safely

The preclinical and phase 1 studies performed with volunteers have confirmed that BMOV is safe and well tolerated in the applied concentrations for further drug development in traumatic conditions such as myocardial infarction and burn wounds. The company is now preparing GMP-manufactured VANADIS® product for clinical phase 1B and 2A trials in several trauma indications, including Myocardial Infarction.